Detalhe da pesquisa
1.
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.
Nature
; 615(7950): 134-142, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36470304
2.
Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19.
J Mol Cell Cardiol
; 167: 92-96, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35339512
3.
Trans-myocardial Extraction of Endothelin-1 Correlates with Increased Microcirculatory Resistance following Percutaneous Coronary Intervention.
J Interv Cardiol
; 2022: 9154048, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36262459
4.
Apelin is expressed throughout the human kidney, is elevated in chronic kidney disease & associates independently with decline in kidney function.
Br J Clin Pharmacol
; 88(12): 5295-5306, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35748053
5.
Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension.
Circulation
; 135(12): 1160-1173, 2017 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28137936
6.
The biased apelin receptor agonist, MM07, reverses Sugen/hypoxia-induced pulmonary arterial hypertension as effectively as the endothelin antagonist macitentan.
Front Pharmacol
; 15: 1369489, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38655187
7.
Co-localization of the sodium-glucose co-transporter-2 channel (SGLT-2) with endothelin ETA and ETB receptors in human cardiorenal tissue.
Biosci Rep
; 2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38747277
8.
Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands.
Front Endocrinol (Lausanne)
; 14: 1139121, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36967803
9.
Inducible apelin receptor knockdown reduces differentiation efficiency and contractility of hESC-derived cardiomyocytes.
Cardiovasc Res
; 119(2): 587-598, 2023 03 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36239923
10.
In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA.
Peptides
; 145: 170642, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34455010
11.
Differential expression in humans of the viral entry receptor ACE2 compared with the short deltaACE2 isoform lacking SARS-CoV-2 binding sites.
Sci Rep
; 11(1): 24336, 2021 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34934117
12.
Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10.
Peptides
; 136: 170440, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33171278
13.
Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection.
Commun Biol
; 4(1): 926, 2021 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34326460
14.
The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo.
Front Pharmacol
; 11: 588669, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33716722
15.
Apelin peptides linked to anti-serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo.
Basic Clin Pharmacol Toxicol
; 126 Suppl 6: 96-103, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-30901161
16.
Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor.
Peptides
; 121: 170139, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31472173
17.
Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans.
Sci Rep
; 9(1): 19934, 2019 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31882594
18.
A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension.
Br J Pharmacol
; 176(9): 1206-1221, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30710493
19.
Immunocytochemical localization of the urotensin-II receptor, UT, to rat and human tissues: relevance to function.
Peptides
; 29(5): 735-42, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17905478
20.
Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure.
Circ Res
; 99(2): 183-90, 2006 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16778132